Adoptive cell therapy for metastatic melanoma patients
Adoptive cell therapy for metastatic melanoma patients
Adoptive cell therapy is provided as experimental treatment for metastatic melanoma patients at the Ella Institute, the Sheba Medical Center, Israel.
Along with other advanced technologies, eligible patients are offered the advanced immunotherapy treatment with TIL (tumor infiltrating lymphocytes).This treatment was developed at the National Institute of Health, US, and very encouraging clinical results have been published by both institutions in the US and Israel*.
*
1. Clin Cancer Res. 2011 17:4550-7.
Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy.
Rosenberg SA, Yang JC, Sherry RM, Kammula US, Hughes MS, Phan GQ, Citrin DE, Restifo NP, Robbins PF, Wunderlich JR, Morton KE, Laurencot CM, Steinberg SM, White DE, Dudley ME.
2. Clin Cancer Res. 2010 16:2646-55.
Clinical responses in a phase II study using adoptive transfer of short-term cultured tumor infiltration lymphocytes in metastatic melanoma patients.
Besser MJ, Shapira-Frommer R, Treves AJ, Zippel D, Itzhaki O, Hershkovitz L, Levy D, Kubi A, Hovav E, Chermoshniuk N, Shalmon B, Hardan I, Catane R, Markel G, Apter S, Ben-Nun A, Kuchuk I, Shimoni A, Nagler A, Schachter J
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