Regenerative Therapy

“Concise review: Transplantation of human hematopoietic cells for extracellular matrix protein deficiency in epidermolysis bullosa.”
“Healthy donor cells from the hematopoietic graft migrate to the injured skin; simultaneously, there is an increase in the production of collagen type VII, increased skin integrity, and reduced tendency to blister formation.”
Tolar J, Blazar BR, Wagner JE. 
Published in:
Stem Cells. 2011 Jun;29(6):900
http://www.ncbi.nlm.nih.gov/pubmed/21557391

“Reversal of type 1 diabetes via islet beta cell regeneration following immune modulation by cord blood-derived multipotent stem cells.”
Zhao y. et al 2012 BMC Med. 10;10(1):3
“Stem Cell Educator therapy can markedly improve C-peptide levels, reduce the median glycated hemoglobin A1C (HbA1C) values, and decrease the median daily dose of insulin in patients with some residual beta cell function (n = 6) and patients with no residual pancreatic islet beta cell function (n = 6). Treatment …

Reversal of type 1 diabetes via islet beta cell regeneration following immune modulation by cord blood-derived multipotent stem cells
Yong Zhao, Zhaoshun Jiang, Tingbao Zhao, Mingliang Ye, Chengjin Hu, Zhaohui Yin, Heng Li, Ye Zhang, Yalin Diao, Yunxiang Li, Yingjian Chen, Xiaoming Sun, Mary Beth Fisk, Randal Skidgel, Mark Holterman, Bellur Prabhakar and Theodore Mazzon
BMC Medicine 2012, 10:3  http://www.biomedcentral.com/1741-7015/10/3/abstract
“A procedure for Stem Cell Educator therapy in which a patient’s blood is circulated through a closed-loop system that separate lymphocytes from the whole blood and briefly co-cultures them with adherent CB-SCs before returning them …

Outcome of unrelated umbilical cord blood transplantation in 88 patients with primary immunodeficiency in Japan.
Morio T, Atsuta Y, Tomizawa D, Nagamura-Inoue T, Kato K, Ariga T, Kawa K, Koike K, Tauchi H, Kajiwara M, Hara T, Kato S; Japanese Cord Blood Bank Network.
Department of Paediatrics and Developmental Biology, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo, Japan.
“Umbilical cord blood transplantation (UCBT) performed in 88 patients with primary immunodeficiency (PID) between …

“Safety and feasibility of autologous bone marrow cellular therapy in relapsing-progressive multiple sclerosis.”
Clin Pharmacol Ther. 2010 Jun;87(6):679-85
Rice CM et al.
SourceInstitute of Clinical Neurosciences, University of Bristol, Frenchay Hospital, Bristol, UK.
“In this phase I study, we assessed the safety and feasibility of intravenous, autologous bone marrow (BM) cell therapy, without immunosuppressive preconditioning, in six patients with clinically definite, relapsing-progressive multiple sclerosis (MS)”
“The lack of serious adverse effects and the suggestion of a beneficial effect in this …

The most significant case for disease eradication after adoptive cell therapy is the TIL treatment.
A recent review summarizes the clinical data: Nat Rev Clin Oncol. 2011 Aug 2. Cell transfer immunotherapy for metastatic solid cancer-what clinicians need to know. Rosenberg SA; Medscape.
“Cancer immunotherapy using the adoptive transfer of autologous tumor-infiltrating lymphocytes results in objective cancer regression in 49-72% of patients with metastatic melanoma. In a pilot trial combining cell transfer with a maximum lymphodepleting regimen, …

Outcome of unrelated umbilical cord blood transplantation in 88 patients with primary immunodeficiency in Japan
Patients with  severe combined immunodeficiency (SCID, n = 40), Wiskott–Aldrich syndrome (WAS, n = 23), chronic granulomatous disease (n = 7), severe congenital neutropaenia (SCN, n = 5) and other immunodeficiencies (n = 13) treated with unrelated umbilical cord blood.
Source: Br J Haematol. 2011 May 14
http://www.ncbi.nlm.nih.gov/pubmed/21569009

Amyotrophic Lateral Sclerosis (ALS) – Clinical Updates Review
Keren Shternhall PhD
Introduction
Amyotrophic lateral sclerosis (ALS- known also as Lou Gehrig’s disease) is one of the most common neurodegenerative diseases of the motor neuron system. ALS is a rapidly progressive fatal neurological disorder that affects nerve cells in the brain and the spinal cord (called “motor neurons”) which are responsible for controlling voluntary muscles.
 The disease is characterized by degeneration and death of motor neurons that leads to miscommunication …

“Autologous hematopoietic stem cell transplantation in 48 patients with end-stage chronic liver diseases”
36 patients with chronic end-stage hepatitis C-induced liver disease and 12 with end-stage autoimmune liver disease. For all patients, granulocyte colony-stimulating factor was administered to mobilize their hematopoietic stem cells. Following leukapheresis, CD34(+) stem cells were isolated, amplified, and partially differentiated in culture, then reinjected into each subject via their hepatic artery or portal vein.
The results suggest that autologous CD34(+) stem cell transplantation …

Treatment of children with severe aplastic anemia with allogeneic cord blood stem cells transplantation.
“ This result suggests that CBT using optimal conditioning regimens can be a salvage treatment for patients without a suitable bone marrow donor and warrants further prospective studies.”
Reported in :
J Pediatr Hematol Oncol. 2010 Nov 18.  Jaing TH et al.
Cord Blood Transplantation in Children With Relapsed or Refractory Severe Aplastic Anemia.
http://www.ncbi.nlm.nih.gov/pubmed/21088620
Mackay Memorial Hospital, Taipei, Taiwan.