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Therapies and Technologies

Clinical Studies, Therapies and Technologies »

[7 Feb 2013 | No Comment | ]
Mesenchymal precursor cells for treatment of rheumatoid arthritis

“MESOBLAST RECEIVES FDA CLEARANCE FOR PHASE 2 CLINICAL TRIAL OF MESENCHYMAL
PRECURSOR CELLS IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS”
Phase II clinical study will be conducted in multiple sites in the United States and Australia.
Source: Mesoblast Ltd.    www.mesoblast.com

Headline, Therapies and Technologies »

[4 Feb 2013 | No Comment | ]
Treatment of hematological malignancies with expanded cord blood stem cells

“Gamida Cell announced today that its flagship product, StemEx, reached its primary endpoint of improving overall survival in a Phase II/III study which compared the use of StemEx as part of a transplantation regimen to historical controls in the treatment of patients with hematological malignancies such as leukemia and lymphoma.”
The product is a graft of an expanded population o hematopoieticf stem/progenitor cells, derived from part of a single unit of umbilical cord blood and transplanted …

Clinical Studies, Therapies and Technologies »

[15 Jan 2013 | No Comment | ]
Spinal fusion treatment by mesenchymal stem cells

Source:
Company press release:
“MESOBLAST’S NEOFUSE STEM CELL PRODUCT SHOWS POSITIVE RESULTS
IN PHASE 2 LUMBAR SPINAL FUSION TRIAL”
The benefit will be eliminating the need for an autograft bone harvest and avoid the risks of this procedure, including pain, infection and blood loss.
www.mesoblast.com  Melbourne, Australia

Clinical Studies, Scientific clinical articles, Therapies and Technologies »

[8 Jan 2013 | No Comment | ]
Double cord transplant- hematopoietic expansion with mesenchymal stem cells

Improvement of engraftment of blood stem cells following ex vivo expansion in co-culture with mesenchymal stem cells.
Clinical results of study in 31 patients with hematologic cancers following transplantation of two cord blood units.
Source:
Cord Blood Engraftment with Ex Vivo Mesenchymal-Cell Coculture
Marcos de Lima et al. N Engl J Med. 2012 Dec 13;367(24):2305-15
http://www.ncbi.nlm.nih.gov/pubmed/23234514

Clinical Studies, Therapies and Technologies »

[12 Dec 2012 | No Comment | ]
Treatment of ALS with reprogrammed stem cells

About 75 percent of amyotrophic lateral sclerosis (ALS) patients who received neural reprogrammed stem cell therapy have shown a mild positive response to the procedure.
Source: http://www.prnewswire.com
Company website: http://www.precisionstemcell.com/index.cfm
Gulf Shores, Alabama
Principal Investigator:  Dr. Jason R. Williams

Clinical Studies, Therapies and Technologies »

[4 Dec 2012 | No Comment | ]
Double cord blood transplant improvement

Fate Therapeutics, Inc., announced today the initiation of a randomized, controlled, Phase 2 multi-center study of its investigational hematopoietic stem cell therapy, ProHema, in adult patients undergoing double umbilical cord blood transplantation for hematologic malignancy.
“ProHema is produced through a proprietary, two-hour, ex vivo modulation process, which has been shown to significantly activate key biological pathways involved in hematopoietic stem cell homing, proliferation and survival in preclinical models.”
Source: company press release -
http://www.fatetherapeutics.com/fate-therapeutics-initiates-phase-2-clinical-study-of-prohema-for-the-treatment-of-hematologic-malignancies/?elq=386ea81455504435b409ef1bc94c1989
Company website: http://www.fatetherapeutics.com

Therapies and Technologies »

[10 Oct 2012 | No Comment | ]
Cord blood product approved by FDA

FDA Approves DUCORD Product from Duke for Stem Cell Transplants
“DUCORD is approved for use in hematopoietic stem cell transplantation for patients with disorders affecting the hematopoietic system that are inherited, acquired, or result from myeloablative treatment.”
Duke, North Carolina, USA
http://www.dukehealth.org/health_library/news/fda-approves-ducord-product-from-duke-for-stem-cell-transplants

Clinical Studies, Therapies and Technologies »

[17 Jul 2012 | No Comment | ]
Treatment of perianal fistulas with stem cells

“TiGenix enrolls first patients in pivotal Phase III trial
with lead product Cx601 in perianal fistulas
ADMIRE CD trial to enroll over 200 patients in 46 centers
across 8 countries.”
Press Release: http://www.tigenix.com/public/uploads/pdf/en/f4ffbd7471a4a24.76706543_120710_TiGenix_Press%20Release_Phase_III_Cx601_ENG.pdf?elq=7e9afdd9f0954178a69fff1065d0a977
Tigenix Belgium http://www.tigenix.com/

Clinical Studies, Therapies and Technologies »

[15 May 2012 | No Comment | ]
Cartilage Repair – Tissue Implant

Regenerative medicine company Histogenics Corporation, announced today the presentation of intermediate term data supporting the clinical efficacy of the Company’s NeoCart Autologous Cartilage Tissue Implant (ACTI) for periods of up to five years with no evidence of severe treatment-related adverse events in patients with grade III chondral injury to the femur (cartilage damage in the knee).
NeoCart® is an implant grown ex vivo (outside the body) from the patient’s own cartilage cells.
NeoCart recently entered a Phase …

Clinical Studies, Scientific clinical articles, Therapies and Technologies »

[12 Jan 2012 | No Comment | ]
Diabetes type1 treatment by ex vivo immune modulation

Reversal of type 1 diabetes via islet beta cell regeneration following immune modulation by cord blood-derived multipotent stem cells
Yong Zhao, Zhaoshun Jiang, Tingbao Zhao, Mingliang Ye, Chengjin Hu, Zhaohui Yin, Heng Li, Ye Zhang, Yalin Diao, Yunxiang Li, Yingjian Chen, Xiaoming Sun, Mary Beth Fisk, Randal Skidgel, Mark Holterman, Bellur Prabhakar and Theodore Mazzon
BMC Medicine 2012, 10:3  http://www.biomedcentral.com/1741-7015/10/3/abstract
“A procedure for Stem Cell Educator therapy in which a patient’s blood is circulated through a closed-loop system that separate lymphocytes from the whole blood and briefly co-cultures them with adherent CB-SCs before returning them …