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Home » Clinical Studies, Scientific clinical articles, Therapies and Technologies

Diabetes type1 treatment by ex vivo immune modulation

12 January 2012 Please Comment
Diabetes type1 treatment by ex vivo immune modulation

Reversal of type 1 diabetes via islet beta cell regeneration following immune modulation by cord blood-derived multipotent stem cells

Yong ZhaoZhaoshun JiangTingbao ZhaoMingliang YeChengjin HuZhaohui YinHeng LiYe ZhangYalin DiaoYunxiang LiYingjian ChenXiaoming SunMary Beth FiskRandal SkidgelMark HoltermanBellur Prabhakar and Theodore Mazzon

BMC Medicine 2012, 10:3  http://www.biomedcentral.com/1741-7015/10/3/abstract

“A procedure for Stem Cell Educator therapy in which a patient’s blood is circulated through a closed-loop system that separate lymphocytes from the whole blood and briefly co-cultures them with adherent CB-SCs before returning them to the patient’s circulation. In an open-label, phase1/phase 2 study, patients (n = 15) with T1D received one treatment with the Stem Cell Educator. Median age was 29 years (range, 15 to 41), and median diabetic history was 8 years (range, 1 to 21).”

Stem Cell Educator therapy was well tolerated and can markedly improve C-peptide levels, reduce the median glycated hemoglobin A1C (HbA1C) values, and decrease the median daily dose of insulin in patients with some residual beta cell function (n = 6) and patients with no residual pancreatic islet beta cell function (n = 6). Treatment also produced an increase in basal and glucose-stimulated C-peptide levels through 40 weeks.

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